Quinone Reductase

Quinones, a class of organic compounds, are formally derived from aromatic compounds and are a subset of the quinoid family which also contains the quinone imines and the quinone methides. NQO1 (QR1, EC 1.6.99.2), also referred to as DT-diaphorase (formerly), nicotinamide quinone oxidoreductase 1, quinone reductase type 1, or menadione reductase, is a cytosolic flavoenzyme. Another member of the quinone oxidoreductases family is NQO2 (QR2, EC 1.10.99.2) which is also a FAD bound protein (25 kDa) and closely related to NQO1. In addition to NQO1 and NQO2 found in humans, an ancient NQO3 subfamily exists in eubacteria, NQO4 subfamily in fungi, and NQO5 subfamily in archaebacteria^[1]^[2].

References:

[1]. Rashid MH, et al. Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants. Chem Biol Interact. 2021 Aug 25;345:109574.

[2]. Cuendet M, et al. Quinone reductase induction as a biomarker for cancer chemoprevention. J Nat Prod. 2006 Mar;69(3):460-3.

Quinone Reductase Related Products (44):

By Effects:	Inhibitors (20) Substrates (5) Activators (13) Modulator (1) Inducers (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0645

Dicoumarol	Inhibitor	99.89%
Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-110258

ML334	Activator	99.76%
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

HY-19734

NK-252	Activator	99.60%
NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

HY-30267

4-Hydroxyphenyl acetate	Activator	99.98%
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor.

HY-100367

ES 936	Inhibitor	98.66%
ES 936 is a potent and specific NQO1 inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). NQO1 is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research.

HY-128895A

KL1333 hydrochloride	Modulator
KL1333 hydrochloride is an orally active NAD⁺ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD⁺ levels through NADH oxidation. Elevated NAD⁺ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures.

HY-174807

NPB-1575	Inhibitor
NPB-1575 is a potent, orally active and brain-penetrant anti-inflammatory agent. NPB-1575 mitigates neuroinflammation and resists ferroptosis by activating the IRS2/Nrf2/NF-κB axis. NPB-1575 shows protective effect against cerebral ischemic injury and improve the neurological functional prognosis. NPB-1575 can be used for the study of ischemic stroke.

HY-176720

NQO1 inducer 1	Inducer
NQO1 inducer 1 (Compound 20) is a potent NQO1 inducer (CD=3 μM). NQO1 inducer 1 is a promising antioxidant that can be used for the research of redox-modulating.

HY-128895

KL1333	Substrate	99.94%
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures.

HY-12346

FH1	Inhibitor	99.17%
FH1 (NSC 12407) is a NQO2 inhibitor with hepatoprotective effects. FH1 enhances hepatocyte function and promotes differentiation of induced pluripotent stem (iPS)-derived hepatocytes to a more mature phenotype and maturation of well-differentiated hepatocyte-like cell (iHeps) cultures. FH1 protects against Acetaminophen (HY-66005)-induced hepatotoxicity in both embryos and adult zebrafish.

HY-13543

Tretazicar	Inhibitor	99.65%
Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1).

HY-W011370

Pelargonidin chloride	Activator	99.10%
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment.

HY-15673

KP372-1	Inhibitor	99.5%
KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer).

HY-103667

2-HBA	Inducer	99.46%
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

HY-125027

Isobutyl-deoxynyboquinone	Substrate	99.70%
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer.

HY-N7093

Furaneol	Activator	99.87%
Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.

HY-N0606

Ginsenoside Rh3	Inhibitor	99.95%
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.

HY-114315

NQO1 substrate	Substrate	98.02%
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC.

HY-108992

Deoxynyboquinone	Inhibitor	99.21%
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation.

HY-N7335

Dehydroglyasperin C	Inhibitor	99.12%
Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.

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